Characterization of the Novel CMT Enzyme TEM-154.

نویسندگان

  • Frédéric Robin
  • Julien Delmas
  • Elisabete Machado
  • Bernadette Bouchon
  • Luísa Peixe
  • Richard Bonnet
چکیده

TEM-154, identified in Portugal in 2004, associated the substitutions observed in the extended-spectrum β-lactamase (ESBL) TEM-12 and in the inhibitor-resistant penicillinase (IRT) TEM-33. This enzyme exhibited hydrolytic activity against ceftazidime and a low level of resistance to clavulanic acid. Surprisingly, the substitution Met69Leu enhanced the catalytic efficiency of oxyimino β-lactams conferred by the substitution Arg164Ser. Its discovery confirms the dissemination of the complex mutant group of TEM enzymes in European countries.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 55 3  شماره 

صفحات  -

تاریخ انتشار 2011